There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

Non-alcoholic fatty liver disease (NAFLD) is a term that covers a range of hepatic disorders
involving fat deposits in the liver. NAFLD begins with simple steatosis and progresses into …

The authors review the current data on the presence and reported biological effects in fish of
some of the most commonly detected pharmaceuticals in the aquatic environment; namely …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

The discovery of the colocalization of catalase with H2O2-generating oxidases in
peroxisomes was the first indication of their involvement in the metabolism of oxygen …

▪ Abstract β-Oxidation occurs in both mitochondria and peroxisomes. Mitochondria catalyze
the β-oxidation of the bulk of short-, medium-, and long-chain fatty acids derived from diet …

PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is
reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to …

Background Polyvinyl chloride plastics (PVC), made flexible through the addition of di‐2‐
ethylhexyl phthalate (DEHP), are used in the production of a wide array of medical devices …

Fatty acid-binding proteins (FABPs) are members of a superfamily of lipid-binding proteins,
and occur intracellularly in vertebrates and invertebrates. This review presents recent …