Context-dependent TGFβ family signalling in cell fate regulation

L Richardson, SG Wilcockson, L Guglielmi… - … Reviews Molecular Cell …, 2023 - nature.com
The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Transforming growth factor-β regulation of immune responses

MO Li, YY Wan, S Sanjabi, AKL Robertson… - Annu. Rev …, 2006 - annualreviews.org
Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Etiopathogenesis of autoimmune hepatitis

A Floreani, P Restrepo-Jiménez, MF Secchi… - Journal of …, 2018 - Elsevier
Autoimmune hepatitis is a chronic inflammatory liver disease characterized by
hypergammaglobulinemia, the presence of autoantibodies, and inflammation within the …

Cellular and molecular basis for the regulation of inflammation by TGF-β

A Yoshimura, Y Wakabayashi… - The journal of …, 2010 - academic.oup.com
Transforming growth factor-β (TGF-β) has been shown to play an essential role in the
suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in …

Transforming growth factor-β and the immune response: implications for anticancer therapy

SH Wrzesinski, YY Wan, RA Flavell - Clinical cancer research, 2007 - AACR
Immune homeostasis is a delicate balance between the immune defense against foreign
pathogens and suppression of the immune system to maintain self-tolerance and prevent …

'Yin–Yang'functions of transforming growth factor‐β and T regulatory cells in immune regulation

YY Wan, RA Flavell - Immunological reviews, 2007 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) and forkhead box p3‐expressing T‐regulatory (Treg)
cells are critical in maintaining self‐tolerance and immune homeostasis. The immune …

TGF-β function in immune suppression

A Yoshimura, G Muto - Negative co-receptors and ligands, 2011 - Springer
Transforming growth factor-β (TGF-β) has been shown to play an essential role in
establishing immunological tolerance, yet recent studies have revealed the pro-inflammatory …

Cellular and molecular mechanisms of autoimmune hepatitis

GJ Webb, GM Hirschfield, EL Krawitt… - Annual Review of …, 2018 - annualreviews.org
Autoimmune hepatitis is an uncommon idiopathic syndrome of immune-mediated
destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is …

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

N Zhang, MJ Bevan - Nature immunology, 2012 - nature.com
T cell–specific deletion of the receptor for transforming growth factor-β (TGF-β) mediated by
Cre recombinase expressed early in T cell development leads to early-onset lethal …

TGF-β and regulatory T cell in immunity and autoimmunity

YY Wan, RA Flavell - Journal of clinical immunology, 2008 - Springer
Introduction The immune response is controlled by several inhibitory mechanisms. These
mechanisms include regulatory T cells, which exist in multiple classes. Notable among these …