Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …
A Floreani, P Restrepo-Jiménez, MF Secchi… - Journal of …, 2018 - Elsevier
Autoimmune hepatitis is a chronic inflammatory liver disease characterized by hypergammaglobulinemia, the presence of autoantibodies, and inflammation within the …
A Yoshimura, Y Wakabayashi… - The journal of …, 2010 - academic.oup.com
Transforming growth factor-β (TGF-β) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in …
SH Wrzesinski, YY Wan, RA Flavell - Clinical cancer research, 2007 - AACR
Immune homeostasis is a delicate balance between the immune defense against foreign pathogens and suppression of the immune system to maintain self-tolerance and prevent …
Transforming growth factor‐β (TGF‐β) and forkhead box p3‐expressing T‐regulatory (Treg) cells are critical in maintaining self‐tolerance and immune homeostasis. The immune …
A Yoshimura, G Muto - Negative co-receptors and ligands, 2011 - Springer
Transforming growth factor-β (TGF-β) has been shown to play an essential role in establishing immunological tolerance, yet recent studies have revealed the pro-inflammatory …
Autoimmune hepatitis is an uncommon idiopathic syndrome of immune-mediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is …
N Zhang, MJ Bevan - Nature immunology, 2012 - nature.com
T cell–specific deletion of the receptor for transforming growth factor-β (TGF-β) mediated by Cre recombinase expressed early in T cell development leads to early-onset lethal …
YY Wan, RA Flavell - Journal of clinical immunology, 2008 - Springer
Introduction The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these …