IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
[HTML][HTML] Adaptive immune receptor germline gene variation
MM Corcoran, GBK Hedestam - Current Opinion in Immunology, 2024 - Elsevier
Recognition of antigens by T cell receptors (TCRs) and B cell receptors (BCRs) is a key step
in lymphocyte activation. T and B cells mediate adaptive immune responses, which protect …
in lymphocyte activation. T and B cells mediate adaptive immune responses, which protect …
[HTML][HTML] Adaptive immune receptor genotyping using the corecount program
S Narang, M Kaduk, M Chernyshev… - Frontiers in …, 2023 - frontiersin.org
We present a new Rep-Seq analysis tool called corecount, for analyzing genotypic variation
in immunoglobulin (IG) and T cell receptor (TCR) genes. corecount is highly efficient at …
in immunoglobulin (IG) and T cell receptor (TCR) genes. corecount is highly efficient at …
Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing
Immunoglobulin loci-transgenic animals are widely used in antibody discovery and
increasingly in vaccine response modelling. In this study, we phenotypically characterised B …
increasingly in vaccine response modelling. In this study, we phenotypically characterised B …
[HTML][HTML] Germline-encoded specificities and the predictability of the B cell response
MC Vieira, AKE Palm, CT Stamper, ME Tepora… - PLoS …, 2023 - journals.plos.org
Antibodies result from the competition of B cell lineages evolving under selection for
improved antigen recognition, a process known as affinity maturation. High-affinity …
improved antigen recognition, a process known as affinity maturation. High-affinity …
Characterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains
JT Kos, Y Safonova, KM Shields, CA Silver, WD Lees… - BioRxiv, 2022 - biorxiv.org
The light chain immunoglobulin genes of biomedically relevant mouse strains are poorly
documented in current germline gene databases. We previously showed that IGH loci of wild …
documented in current germline gene databases. We previously showed that IGH loci of wild …
Immunoglobulin genes, reproductive isolation and vertebrate speciation
Reproductive isolation drives the formation of new species, and many genes contribute to
this through Dobzhansky–Muller incompatibilities (DMIs). These incompatibilities occur …
this through Dobzhansky–Muller incompatibilities (DMIs). These incompatibilities occur …
[HTML][HTML] AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets
Abstract Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can
provide important insights into immune function. High-quality analysis of adaptive immune …
provide important insights into immune function. High-quality analysis of adaptive immune …
IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
[图书][B] Defining human adaptive immune gene diversity
S Narang - 2024 - openarchive.ki.se
The lymphocytes (B and T cells) of the adaptive immune system undergo variable (V),
diversity (D), and junctional (J) gene recombination, resulting in highly diverse antigen …
diversity (D), and junctional (J) gene recombination, resulting in highly diverse antigen …