During life, bone undergoes modelling and remodelling in order to grow or change shape.
Bone modelling is the process by which bones change shape or size in response to …

This review describes normal bone anatomy and physiology as an introduction to the
subsequent articles in this section that discuss clinical applications of iliac crest bone biopsy …

Bone, a highly specialized supporting framework of the body, is characterized by its rigidity
and hardness and is endowed with the power of regeneration and repair. Its formation is …

The bone replacement process in the adult skeleton is known as remodeling. When bone is
removed by osteoclasts, new bone is laid down by osteoblasts in the same place, because …

Although mechanical stabilisation has been a hallmark of orthopaedic surgical
management, orthobiologics are now playing an increasing role. Platelet-rich plasma (PRP) …

When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth
factor β1 (TGF-β1), terminal differentiation into myotubes is blocked. Treatment with bone …

Bone tissue engineering has emerged as one of the leading fields in tissue engineering and
regenerative medicine. The success of bone tissue engineering relies on understanding the …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

The success of an implant is determined by its integration into the tissue surrounding the
biomaterial. Surface roughness and composition are considered to influence the properties …

Sex steroids are essential for skeletal development and the maintenance of bone health
throughout adult life, and estrogen deficiency at menopause is a major pathogenetic factor …