EM Bevers, PL Williamson - Physiological reviews, 2016 - journals.physiology.org
Phosphatidylserine (PS) is a major component of membrane bilayers whose change in distribution between inner and outer leaflets is an important physiological signal. Normally …
The calcium-activated chloride channel TMEM16A is a ligand-gated anion channel that opens in response to an increase in intracellular Ca2+ concentration,,. The protein is …
JD Brunner, NK Lim, S Schenck, A Duerst, R Dutzler - Nature, 2014 - nature.com
The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional diversity. This family contains the long sought-after Ca2+-activated chloride channels as well …
SY Graeber, MA Mall - The Lancet, 2023 - thelancet.com
With the 2019 breakthrough in the development of highly effective modulator therapy providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …
K Tengvall, J Huang, C Hellström… - Proceedings of the …, 2019 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory, likely autoimmune disease of the central nervous system with a combination of genetic and environmental risk factors, among which …
Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy– while some family members function as Ca 2+-activated anion channels, the majority of …
S Nagata, T Sakuragi, K Segawa - Current Opinion in Immunology, 2020 - Elsevier
Highlights•Phospholipid scramblases, responsible for the PtdSer-exposure in activated platelets and apoptotic cells, were identified.•Distinct mechanisms mediate PtdSer-exposure …