In the quest for separation techniques capable of generating high peak capacities,
comprehensive two-dimensional (2D) liquid chromatography (LC× LC) is a performant …

Today scientists must deal with complex samples that either cannot be adequately
separated using one-dimensional chromatography or that require an inordinate amount of …

The interest in two-dimensional liquid chromatography (2D-LC) has been growing up since
the last decades. This promising technique appears as a relevant solution for various …

In the literature an increasing interest in quantitative structure–retention relationships
(QSRR) can be observed. After a short introduction on QSRR and other strategies proposed …

Online comprehensive two-dimensional liquid chromatography (online LCxLC) presents
high peak capacity compared with one-dimensional liquid chromatography, and reasonable …

Packed column supercritical fluid chromatography (pSFC) is an attractive technique in drug
discovery related analysis because it offers several advantages over the more commonly …

On‐line comprehensive two‐dimensional liquid chromatography techniques promise to
resolve samples that current one‐dimensional liquid chromatography methods cannot …

The understanding, identification, quantification and control of impurities in drug substances
are essential as new molecular entities are evaluated in clinical development. As chemical …

Comprehensive on-line two-dimensional liquid chromatography (on-line LC× LC) was used
for the characterization of bio-oils obtained by fast pyrolysis of lignocellulosic biomass. The …

Hydrophilic interaction chromatography (HILIC) was used in two dimensions in a
comprehensive two-dimensional HILIC hyphenated with a quadrupole time-of-flight mass …