High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Abstract MacInnis, Martin J., and Michael S. Koehle. Evidence for and against genetic
predispositions to acute and chronic altitude illnesses. High Alt Med Biol. 17: 281–293 …

Cancer therapies are being considered for treating rare noncancerous diseases like
pulmonary hypertension (PH), but effective computational screening is lacking. Via …

EGLN1 [encoding HIF (hypoxia-inducible factor)-prolyl hydroxylase 2] plays a pivotal role in
the HIF pathway and has emerged as one of the most intriguing genes with respect to …

Background The interactions among various biomarkers remained unexplored under the
stressful environment of high-altitude. Present study evaluated interactions among …

Hypobaric hypoxia at high altitude (HA) results in reduced blood arterial oxygen saturation,
perfusion of organs with hypoxemic blood, and direct hypoxia of lung tissues. The …

Upon rapid ascent to a high altitude, non-acclimatized individuals, although healthy, are
highly prone to contracting high-altitude pulmonary edema (HAPE). Early diagnosis is …

The effect of high altitude (HA, altitude> 2500 m) can trigger a maladaptive response in
unacclimatized individuals, leading to various HA illnesses such as high altitude pulmonary …

High-altitude retinopathy (HAR) is an ocular manifestation of acute oxygen deficiency at high
altitudes. Although the pathophysiology of HAR has been revealed by many studies in …

High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude
area, which is rapid and harmful. We firstly conducted a case-control study to assess the …