Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
Antivirals against the Chikungunya virus
V Battisti, E Urban, T Langer - Viruses, 2021 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …
Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach
The rapidly spreading, highly contagious and pathogenic SARS-coronavirus 2 (SARS-CoV-
2) associated Coronavirus Disease 2019 (COVID-19) has been declared as a pandemic by …
2) associated Coronavirus Disease 2019 (COVID-19) has been declared as a pandemic by …
[HTML][HTML] Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: Integrated computational …
The spike protein receptor binding domain (S-RBD) is a necessary corona-viral protein for
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
Overview on chikungunya virus infection: from epidemiology to state-of-the-art experimental models
LEC Constant, BF Rajsfus, PH Carneiro… - Frontiers in …, 2021 - frontiersin.org
Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public
health. It is a member of the Togaviridae family and alphavirus genus and causes an …
health. It is a member of the Togaviridae family and alphavirus genus and causes an …
Green synthesis of nanometal impregnated biomass–antiviral potential
Due to the epidemic nature, Chikungunya virus (CHIKV), arthropod-borne alphaviruses, is
considered as a potential public health threat worldwide. Currently, no antiviral drug or …
considered as a potential public health threat worldwide. Currently, no antiviral drug or …
Alphavirus RNA replication in vertebrate cells
T Ahola, G McInerney, A Merits - Advances in virus research, 2021 - Elsevier
Alphaviruses are positive-strand RNA viruses, typically transmitted by mosquitoes between
vertebrate hosts. They encode four essential replication proteins, the non-structural proteins …
vertebrate hosts. They encode four essential replication proteins, the non-structural proteins …
Inhibition of Chikungunya virus by an adenosine analog targeting the SAM‐dependent nsP1 methyltransferase
Alphaviruses, including Chikungunya (CHIKV) and Venezuelan equine encephalitis virus
(VEEV), are among the leading causes of recurrent epidemics all over the world. Alphaviral …
(VEEV), are among the leading causes of recurrent epidemics all over the world. Alphaviral …
Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site
Chikungunya virus (CHIKV), a mosquito-borne pathogenic alphavirus is a growing public
health threat. No vaccines or antiviral drug is currently available in the market for …
health threat. No vaccines or antiviral drug is currently available in the market for …
Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection
Chikungunya virus (CHIKV) is an arthritogenic alphavirus and currently, no antiviral drug is
available to combat it. Capsid protein (CP) of alphaviruses present at the N-terminus of the …
available to combat it. Capsid protein (CP) of alphaviruses present at the N-terminus of the …