The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …

Ketamine exerts rapid antidepressant action in depressed and treatment-resistant
depressed patients within hours. At the same time, ketamine elicits a unique form of …

A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased
sleep quality. Here we show that homeostatic mechanisms transiently counteract the …

Malignant brain tumours are the cause of a disproportionate level of morbidity and mortality
among cancer patients, an unfortunate statistic that has remained constant for decades …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS). Astrocytes are the most abundant glial cells in the CNS, and their dysfunction …

Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis
pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In …

To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …

Developing neural circuits are influenced by activity and are especially sensitive to changes
in activity during critical periods (CPs) of development. Changes occurring during a CP often …