The receptor tyrosine-kinase HER2 (also known as ErbB2) is a well-established therapeutic
target in patients with breast or gastric cancer selected on the basis of HER2 overexpression …

Gastric cancer presents substantial management challenges, and the advent of
immunotherapy has ignited renewed hope among patients. Nevertheless, a significant …

Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in
adults and is highly metastatic, resulting in a poor patient prognosis. Sphingolipid …

Melanoma is a malignant tumor of melanocytes and is often considered immunogenic
cancer. Toll-like receptor-related genes are expressed differently in most types of cancer …

Background: The extremely malignant tumour known as pancreatic cancer (PC) lacks
efficient prognostic markers and treatment strategies. The microbiome is crucial to how …

The extracellular matrix (ECM) is a vital component of the tumor microenvironment, which
interplays with stromal and tumor cells to stimulate the capacity of cancer cells to proliferate …

Colon adenocarcinoma (COAD) is the primary factor responsible for cancer-related
mortalities in western countries, and its development and progression are affected by altered …

Background Regulatory T cells (Tregs), are a key class of cell types in the immune system. In
the tumor microenvironment (TME), the presence of Tregs has important implications for …

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, a
disease with dismal overall survival. Advances in treatment are hindered by a lack of …

Background Current paradigms of anti-tumor therapies are not qualified to evacuate the
malignancy ascribing to cancer stroma's functions in accelerating tumor relapse and …