In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

The strength and efficiency of synaptic connections are affected by the environment or the
experience of the individual. This property, called synaptic plasticity, is directly related to …

Impaired synaptic plasticity and dendritic loss in excitatory glutamatergic synapses are early
events in Alzheimer disease (AD). These synaptic abnormalities are triggered by …

Glutamate is the major excitatory neurotransmitter in the brain, and it is widely accepted to
play a role in synaptic plasticity and excitotoxic cell death. Glutamate binds to several …

Summary Protein phosphatase 2A (PP2A) inhibition causes hyperphosphorylation of tau
and APP in Alzheimer's disease (AD). However, the mechanisms underlying the …

Obesity is known to induce leptin and insulin resistance. Leptin is a peptide hormone
synthesized in adipose tissue that mainly regulates food intake. It has been shown that …

N-Methyl-D-aspartate glutamate receptors (NMDARs) are involved in multiple
physiopathological processes, including synaptic plasticity, neuronal network activities …

Abstract Codonopsis pilosula Polysaccharides (CPPs), a traditional Chinese medicine used
for thousands of years, is a potential neuroprotective polysaccharide via a relatively poorly …