Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …

Single trauma injuries or isolated fractures are often manageable and generally heal without
complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns …

Mast cells (MCs) are important sensor and effector cells of the immune system that are
involved in many physiological and pathological conditions. Increasing evidence suggests …

Carboxypeptidase A3 (CPA3) is a specific mast cell (MC) protease with variable expression.
This protease is one of the preformed components of the secretome. During maturation of …

Canine osteosarcoma is increasingly recognized as an informative model for human
osteosarcoma. Here we show in one of the largest clinically annotated canine osteosarcoma …

In vertebrates, bone is considered an osteoimmune system which encompasses functions of
a locomotive organ, a mineral reservoir, a hormonal organ, a stem cell pool and a cradle for …

Mast cells, important sensor and effector cells of the immune system, may influence bone
metabolism as their number is increased in osteoporotic patients. They are also present …

There is evidence that mast cells contribute to inflammation induced by hemorrhagic shock,
severe tissue injury or sepsis. Mast cells are highly responsive to alarm signals generated …

Mast cells (MCs) are immune cells of the myeloid lineage that are present in the connective
tissue throughout the body and in mucosa tissue. They originate from hematopoietic stem …

Immune homeostasis is delicately mediated by the dynamic balance between effector
immune cells and regulatory immune cells. Local deviations from immune homeostasis in …