[HTML][HTML] Principles for targeting RNA with drug-like small molecules
KD Warner, CE Hajdin, KM Weeks - Nature reviews Drug discovery, 2018 - nature.com
RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
The how and why of lncRNA function: an innate immune perspective
EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
3D RNA and functional interactions from evolutionary couplings
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far
outpaces the research on the structure and functional interactions of these RNA gene …
outpaces the research on the structure and functional interactions of these RNA gene …
Direct-Coupling Analysis of nucleotide coevolution facilitates RNA secondary and tertiary structure prediction
E De Leonardis, B Lutz, S Ratz, S Cocco… - Nucleic acids …, 2015 - academic.oup.com
Despite the biological importance of non-coding RNA, their structural characterization
remains challenging. Making use of the rapidly growing sequence databases, we analyze …
remains challenging. Making use of the rapidly growing sequence databases, we analyze …
Translation: the universal structural core of life
Abstract The Universal Gene Set of Life (UGSL) is common to genomes of all extant
organisms. The UGSL is small, consisting of< 100 genes, and is dominated by genes …
organisms. The UGSL is small, consisting of< 100 genes, and is dominated by genes …
Specificity between lactobacilli and hymenopteran hosts is the exception rather than the rule
ABSTRACT Lactobacilli (Lactobacillales: Lactobacillaceae) are well known for their roles in
food fermentation, as probiotics, and in human health, but they can also be dominant …
food fermentation, as probiotics, and in human health, but they can also be dominant …
In-cell SHAPE reveals that free 30S ribosome subunits are in the inactive state
JL McGinnis, Q Liu, CA Lavender… - Proceedings of the …, 2015 - National Acad Sciences
It was shown decades ago that purified 30S ribosome subunits readily interconvert between
“active” and “inactive” conformations in a switch that involves changes in the functionally …
“active” and “inactive” conformations in a switch that involves changes in the functionally …
RNA structural constraints in the evolution of the influenza A virus genome NP segment
AP Gultyaev, A Tsyganov-Bodounov, MIJ Spronken… - RNA biology, 2014 - Taylor & Francis
Conserved RNA secondary structures were predicted in the nucleoprotein (NP) segment of
the influenza A virus genome using comparative sequence and structure analysis. A number …
the influenza A virus genome using comparative sequence and structure analysis. A number …
Subtype-specific structural constraints in the evolution of influenza A virus hemagglutinin genes
AP Gultyaev, MI Spronken, M Richard… - Scientific reports, 2016 - nature.com
The influenza A virus genome consists of eight RNA segments. RNA structures within these
segments and complementary (cRNA) and protein-coding mRNAs may play a role in virus …
segments and complementary (cRNA) and protein-coding mRNAs may play a role in virus …
Variable region sequences influence 16S rRNA performance
N Bose, SD Moore - Microbiology Spectrum, 2023 - Am Soc Microbiol
ABSTRACT 16S rRNA gene sequences are commonly analyzed for taxonomic and
phylogenetic studies because they contain variable regions that can help distinguish …
phylogenetic studies because they contain variable regions that can help distinguish …