Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

Portable devices capable of rapid disease detection and health monitoring are crucial to
decentralizing diagnostics from clinical laboratories to the patient point-of-need. Although …

Specific and sensitive detection and imaging of cancer-related miRNA in living cells are
desirable for cancer diagnosis and treatment. Because of the spatiotemporal variability of …

An ortho-nitrobenzyl phosphate ester–caged nucleic acid hairpin structure coupled to the
CRISPR-Cas12a complex is introduced as a functional reaction module for the light-induced …

The development of facile, reliable, and accurate assays for pathogenic bacteria is critical to
environmental pollution surveillance, traceability analysis, prevention, and control. Here, we …

Tunable detection of microRNA is crucial to meet the desired demand for sample species
with varying concentrations in clinical settings. Herein, we present a DNA walker-based …

Nucleic acids are widely used in biomedical applications because of their programmability
and biocompatibility. The light responsive nucleic acids have attracted wide attention due to …

The subcellular distribution of adenosine 5′-triphosphate (ATP) and the concentration of
ATP in living cells dynamically fluctuate with time during different cell cycles. The dictated …

“On-demand” accurate imaging of multiple intracellular miRNAs will significantly improve the
detection reliability and accuracy. However, the “always-active” design of traditional …

Portable point-of-care testing (POCT) is currently drawing enormous attention owing to its
great potential for disease diagnosis and personal health management. Electrochemical …