The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

B cell activation and differentiation yields plasma cells with high affinity antibodies to a given
antigen in a time-frame that allows for host protection. Although the end product is most …

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …

Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …

Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …

Following infection or vaccination, activated B cells at extrafollicular sites or within germinal
centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been …

Higher-or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC
recycling, respectively; however, how commitment to the plasma cell fate takes place is …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular
pathogenic B cells derived from newly activated naive cells. Although these cells express …