Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Objectives To unravel the hierarchy of cellular/molecular pathways in the disease tissue of
early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship …

Aim Imbalance of T-helper-cell (TH) subsets (TH1/TH2/TH17) and regulatory T-cells (Tregs)
is suggested to contribute to the pathogenesis of Systemic lupus erythematosus (SLE) …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …

Neutrophils have emerged as important regulators of innate and adaptive immune
responses. Recent evidence indicates that neutrophils display marked abnormalities in …

Since their identification in 2005, T helper (Th) 17 cells have been proposed to play
important roles in several human diseases, including various autoimmune conditions …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by severe joint damage
and disability. However, the specific mechanism of RA has not been thoroughly clarified …