The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …

Chromosomal rearrangements of the human MLL gene are associated with high-risk
pediatric, adult and therapy-associated acute leukemias. These patients need to be …

We have shown that Wnt5A increases the motility of melanoma cells. To explore cellular
pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) …

Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammatory
back pain and spinal ankylosis due to pathological new bone formation. Here, we identified …

Liver metastasis is the major cause of death associated to colorectal cancer. Cadherin-17
(CDH17) is a non-classical, seven domain, cadherin lacking the conserved cytoplasmic …

Inflammation is a major driver of tumor progression and metastasis, although the
mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown …

Human mesenchymal stem cells (hMSCs) exhibit the potential to contribute to a wide variety
of endogenous organ tissue repair. However, the signals governing hMSC mobilization out …

Dissemination of cancer cells from the primary tumor and their spread to distant sites of the
body is the leading cause of mortality in metastatic cancer patients. Metastatic cancer cells …