Activation of the G‐protein‐coupled receptor rhodopsin by water
U Chawla, SMDC Perera, SDE Fried… - Angewandte …, 2021 - Wiley Online Library
Visual rhodopsin is an important archetype for G‐protein‐coupled receptors, which are
membrane proteins implicated in cellular signal transduction. Herein, we show …
membrane proteins implicated in cellular signal transduction. Herein, we show …
HomolWat: a web server tool to incorporate 'homologous' water molecules into GPCR structures
E Mayol, A García-Recio, JKS Tiemann… - Nucleic acids …, 2020 - academic.oup.com
Internal water molecules play an essential role in the structure and function of membrane
proteins including G protein-coupled receptors (GPCRs). However, technical limitations …
proteins including G protein-coupled receptors (GPCRs). However, technical limitations …
Hydration-mediated G-protein–coupled receptor activation
The Rhodopsin family of G-protein–coupled receptors (GPCRs) comprises the targets of
nearly a third of all pharmaceuticals. Despite structural water present in GPCR X-ray …
nearly a third of all pharmaceuticals. Despite structural water present in GPCR X-ray …