Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

The arrangement (syntax) of transcription factor (TF) binding motifs is an important part of the
cis-regulatory code, yet remains elusive. We introduce a deep learning model, BPNet, that …

Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …