Dietary lipids, gut microbiota and lipid metabolism
M Schoeler, R Caesar - Reviews in endocrine and metabolic disorders, 2019 - Springer
The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …
the gut microbiota is dynamic and affected by diet properties such as the amount and …
Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …
Gut microbiota in cardiovascular health and disease
Significant interest in recent years has focused on gut microbiota–host interaction because
accumulating evidence has revealed that intestinal microbiota play an important role in …
accumulating evidence has revealed that intestinal microbiota play an important role in …
Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
Aims Carnitine and choline are major nutrient precursors for gut microbiota-dependent
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …
Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk
Normal platelet function is critical to blood hemostasis and maintenance of a closed
circulatory system. Heightened platelet reactivity, however, is associated with …
circulatory system. Heightened platelet reactivity, however, is associated with …
Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target
S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …
developed countries, and atherosclerosis (AS) is the common pathological basis of many …
Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis
Summary Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite,
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …
Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis
GG Schiattarella, A Sannino, E Toscano… - European heart …, 2017 - academic.oup.com
Aims Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a
new potentially important cause of increased cardiovascular risk. The purpose of this meta …
new potentially important cause of increased cardiovascular risk. The purpose of this meta …
Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction
S Chen, A Henderson, MC Petriello, KA Romano… - Cell metabolism, 2019 - cell.com
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …
resistance and associated with several sequelae of metabolic syndrome in humans …
Role of gut microbiota in atherosclerosis
AL Jonsson, F Bäckhed - Nature Reviews Cardiology, 2017 - nature.com
Infections have been linked to the development of cardiovascular disease and
atherosclerosis. Findings from the past decade have identified microbial ecosystems …
atherosclerosis. Findings from the past decade have identified microbial ecosystems …