The IL-1 family in tumorigenesis and antitumor immunity

R Sun, DS Gao, J Shoush, B Lu - Seminars in cancer biology, 2022 - Elsevier
The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …

Gut Leakage of Fungal‐Related Products: Turning Up the Heat for HIV Infection

S Isnard, J Lin, S Bu, B Fombuena, L Royston… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial layer serves as a physical and functional barrier between the
microbiota in the lumen and immunologically active submucosa. Th17 T-cell function …

Circulating markers of microbial translocation and host response to bacteria with risk of colorectal cancer: a prospective, nested case-control study in men

M Shi, X Zong, J Hur, BM Birmann, O Martinez-Maza… - …, 2023 - thelancet.com
Background Gut microbial dysbiosis contributes to colorectal cancer (CRC) pathogenesis,
possibly mediated in part by increased intestinal permeability to endotoxin …

[HTML][HTML] Gut permeability, inflammation, and bone density across the menopause transition

A Shieh, M Epeldegui, AS Karlamangla… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Inflammation is implicated in many aging-related disorders. In animal
models, menopause leads to increased gut permeability and inflammation. Our primary …

Microbial translocation is linked to a specific immune activation profile in HIV-1-infected adults with suppressed viremia

M Younas, C Psomas, C Reynes, R Cezar… - Frontiers in …, 2019 - frontiersin.org
Persistent immune activation in virologically suppressed HIV-1 patients, which may be the
consequence of various factors including microbial translocation, is a major cause of …

Aging with grace for people living with HIV: strategies to overcome leaky gut and cytomegalovirus coinfection

JP Routy, L Royston, S Isnard - JAIDS Journal of Acquired Immune …, 2022 - journals.lww.com
The intestinal epithelial layer acts as a mechanical and functional barrier between the
intraluminal microbiota and the immunologically active submucosa. A progressive loss of gut …

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

E Untersmayr, HJ Bax, C Bergmann, R Bianchini… - Allergy, 2019 - Wiley Online Library
The microbiota can play important roles in the development of human immunity and the
establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and …

Daily variations of gut microbial translocation markers in ART-treated HIV-infected people

J Ouyang, S Isnard, J Lin, B Fombuena… - AIDS Research and …, 2020 - Springer
Background Increased intestinal barrier permeability and subsequent gut microbial
translocation are significant contributors to inflammatory non-AIDS comorbidities in people …

16S rDNA sequencing analyzes differences in intestinal flora of human immunodeficiency virus (HIV) patients and association with immune activation

Z Mingjun, M Fei, X Zhousong, X Wei, X Jian… - …, 2022 - Taylor & Francis
To clarify the influence of HIV on the intestinal flora and the interrelationship with CD4 T
cells, the present study collected stool specimens from 33 HIV patients and 28 healthy …

Effect of immunological non-response on incidence of Non-AIDS events in people living with HIV: A retrospective multicenter cohort study in Taiwan

CH Wen, PL Lu, CY Lin, YP Lin, TC Chen… - Journal of Microbiology …, 2023 - Elsevier
Background People living with HIV (PLWH) are susceptible to non-AIDS-related events,
particularly those with immunological nonresponses (INRs) to highly active antiretroviral …