Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Astrocyte senescence: evidence and significance

J Cohen, C Torres - Aging cell, 2019 - Wiley Online Library
Astrocytes participate in numerous aspects of central nervous system (CNS) physiology
ranging from ion balance to metabolism, and disruption of their physiological roles can …

T lymphocytes and inflammatory mediators in the interplay between brain and blood in Alzheimer's disease: potential pools of new biomarkers

A Mietelska-Porowska, U Wojda - Journal of immunology …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the main cause of
dementia. The disease is among the leading medical concerns of the modern world …

Viral involvement in Alzheimer's disease

A Sait, C Angeli, AJ Doig, PJR Day - ACS chemical neuroscience, 2021 - ACS Publications
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

[HTML][HTML] Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

A Chandrasekaran, KS Dittlau, GI Corsi, H Haukedal… - Stem cell reports, 2021 - cell.com
Summary Frontotemporal dementia type 3 (FTD3), caused by a point mutation in the
charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and …

Could Alzheimer's disease originate in the periphery and if so how so?

G Morris, M Berk, M Maes, BK Puri - Molecular neurobiology, 2019 - Springer
The classical amyloid cascade model for Alzheimer's disease (AD) has been challenged by
several findings. Here, an alternative molecular neurobiological model is proposed. It is …

HIV-associated cellular senescence: a contributor to accelerated aging

J Cohen, C Torres - Ageing research reviews, 2017 - Elsevier
Due to the advent of antiretroviral therapy HIV is no longer a terminal disease and the HIV
infected patients are becoming increasingly older. While this is a major success, with …

Genetic, transcriptome, proteomic, and epidemiological evidence for blood-brain barrier disruption and polymicrobial brain invasion as determinant factors in …

CJ Carter - Journal of Alzheimer's disease reports, 2017 - content.iospress.com
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey
showed that AD genome-wide association study (GWAS) genes (localized in bone marrow …

Astrocyte senescence and metabolic changes in response to HIV antiretroviral therapy drugs

J Cohen, L D'Agostino, J Wilson, F Tuzer… - Frontiers in aging …, 2017 - frontiersin.org
With the advent of highly active antiretroviral therapy (HAART) survival rates among patients
infected by HIV have increased. However, even though survival has increased HIV …

[HTML][HTML] Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias

A Chen, AE Oakley, M Monteiro, K Tuomela… - Neurobiology of …, 2016 - Elsevier
Both the inflammatory potential and cognitive function decline during aging. The association
between the repertoire of inflammatory biomarkers and cognitive decline is unclear …