As cancer cells undergo metastasis—invasion and migration of a new tissue—they
penetrate and attach to the target tissue's basal matrix. This allows the cancer cell to pull …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Biomedical photonics is defined as the science of harnessing light and other forms of radiant
energy to address problems in medicine and biology. The field has experienced explosive …

Since the advent of the green fluorescent protein, the subcellular localization, mobility,
transport routes and binding interactions of proteins can be studied in living cells. Live cell …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

Networks of signal transducers determine the conversion of environmental cues into cellular
actions. Among the main players in these networks are protein kinases, which can acutely …

The ability of cells to adhere to each other and to their surrounding extracellular matrices is
essential for a multicellular existence. Adhesion provides physical support for cells …

The mechanism by which ECM elasticity induces lineage specification of stem cells has not
been clearly understood. Integrins are well-documented mechanosensors that are …

The transmembrane proteins of the tetraspanin superfamily are implicated in a diverse
range of biological phenomena, including cell motility, metastasis, cell proliferation and …