The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

INTRODUCTION The hematopoietic road map is a compilation of the various lineage
differentiation routes that a stem cell takes to make blood. This program produces greater …

Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …

Ever since hematopoietic stem cells (HSCs) were first identified half a century ago, their
differentiation roadmap has been extensively studied. The classical model of hematopoiesis …

Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …

Consensus holds that hematopoietic stem cells (HSCs) give rise to multipotent progenitors
(MPPs) of reduced self-renewal potential and that MPPs eventually produce lineage …

Immune system defects are at the center of aging and a range of diseases. Here, we show
that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell …

In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …