The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation

C Whittaker, C Dean - Annual review of cell and developmental …, 2017 - annualreviews.org
Our understanding of the detailed molecular mechanisms underpinning adaptation is still
poor. One example for which mechanistic understanding of regulation has converged with …

Epigenetics for plant improvement: current knowledge and modeling avenues

P Gallusci, Z Dai, M Génard, A Gauffretau… - Trends in plant …, 2017 - cell.com
Epigenetic variations are involved in the control of plant developmental processes and
participate in shaping phenotypic plasticity to the environment. Intense breeding has eroded …

Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization

T Csorba, JI Questa, Q Sun… - Proceedings of the …, 2014 - National Acad Sciences
Long noncoding RNAs (lncRNAs) have been proposed to play important roles in gene
regulation. However, their importance in epigenetic silencing and how specificity is …

Vernalization-triggered intragenic chromatin loop formation by long noncoding RNAs

DH Kim, S Sung - Developmental cell, 2017 - cell.com
Long noncoding RNAs (lncRNAs) affect gene regulation through structural and regulatory
interactions with associated proteins. The Polycomb complex often binds to lncRNAs in …

Transposition favors the generation of large effect mutations that may facilitate rapid adaption

L Quadrana, M Etcheverry, A Gilly, E Caillieux… - Nature …, 2019 - nature.com
Transposable elements (TEs) are mobile parasitic sequences that have been repeatedly
coopted during evolution to generate new functions and rewire gene regulatory networks …

R-Loop Stabilization Represses Antisense Transcription at the Arabidopsis FLC Locus

Q Sun, T Csorba, K Skourti-Stathaki, NJ Proudfoot… - Science, 2013 - science.org
Roles for long noncoding RNAs (lncRNAs) in gene expression are emerging, but regulation
of the lncRNA itself is poorly understood. We have identified a homeodomain protein …

Epigenetic regulation in plant responses to the environment

DC Baulcombe, C Dean - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
In this article, we review environmentally mediated epigenetic regulation in plants using two
case histories. One of these, vernalization, mediates adaptation of plants to different …

Environmental perception and epigenetic memory: mechanistic insight through FLC

S Berry, C Dean - The Plant Journal, 2015 - Wiley Online Library
Chromatin plays a central role in orchestrating gene regulation at the transcriptional level.
However, our understanding of how chromatin states are altered in response to …

Histone methylation in epigenetic regulation and temperature responses

K He, X Cao, X Deng - Current Opinion in Plant Biology, 2021 - Elsevier
Methylation of histones on different lysine residues is dynamically added by distinct writer
enzymes, interpreted by reader proteins, and removed by eraser enzymes. This epigenetic …

Vernalization–a cold-induced epigenetic switch

J Song, A Angel, M Howard… - Journal of cell science, 2012 - journals.biologists.com
Growth and development are modulated by environmental signals in many organisms.
These signals are often perceived at one stage and 'remembered'until later in development …