RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

RNA-programmed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has
enabled rapid and accessible alteration of specific genomic loci in many organisms. A …

Efficient targeted control of splicing is a major goal of functional genomics and therapeutic
applications. Guide (g) RNA-directed, deactivated (d) Cas CRISPR enzymes fused to …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

RNAP II is frequently paused near gene promoters in mammals, and its transition to
productive elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for …

Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,
yet how this process is regulated by oncogenic signal remains largely unknown. Here, we …

Phase-separated membraneless bodies play important roles in nucleic acid biology. While
current models for the roles of phase separation largely focus on the compartmentalization …

Splicing dysregulation is one of the molecular hallmarks of cancer. However, the underlying
molecular mechanisms remain poorly defined. Here we report that the splicing factor RBM4 …

RNA binding proteins of the conserved CUGBP1, Elav-like factor (CELF) family contribute to
heart and skeletal muscle development and are implicated in myotonic dystrophy (DM). To …