A core component to corticolimbic circuitry is the GABAergic interneuron. Neuroanatomic
studies conducted over the past century have demonstrated several subtypes of interneuron …

Data from animal models and from postmortem studies suggest that schizophrenia is
associated with brain GABAergic dysfunction. The extent to which this is reflected in data …

There is an urgent need to improve the pharmacotherapy of schizophrenia despite the
introduction of important new medications. New treatment insights may come from …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …

Abnormalities of GABAergic interneurons are some of the most consistent findings from post-
mortem studies of schizophrenia. However, linking these molecular deficits with in vivo …

Objective: Postmortem studies in schizophrenia reveal alterations in gene products that
regulate the release and extracellular persistence of GABA. However, results of in vivo …

This review gives an overview of those in vivo imaging studies on synaptic
neurotransmission, which so far have been performed on patients with mental and affective …

Gamma-amino butyric acid (GABA) is thought to play a role in the pathophysiology of
schizophrenia. High magnetic field proton magnetic resonance spectroscopy (1H-MRS) …

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is
documented. From its early use as a general anesthetic, chemical model of schizophrenia …