Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …

ABSTRACT Manganese (Mn2+) is an essential trace element within organisms spanning
the entire tree of life. In this review, we provide an overview of Mn2+ transport and the …

Conspectus Natural metalloenzymes are often the most proficient catalysts in terms of their
activity, selectivity, and ability to operate at mild conditions. However, metalloenzymes are …

Manganese (M n) is a required cofactor for all forms of life. Given the importance of M n to
bacteria, the host has devised strategies to sequester M n from invaders. In the macrophage …

In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase
(RNR), the enzyme responsible for biosynthesis of the 2′-deoxynucleotide building blocks …

Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a
significant threat to public health. The human innate immune system represents the first line …

Redox reactions are central to biochemistry and are both controlled by and induce protein
structural changes. Here, we describe structural rearrangements and crosstalk within the …

All cells obtain 2′-deoxyribonucleotides for DNA synthesis through the activity of a
ribonucleotide reductase (RNR). The class I RNRs found in humans and pathogenic …

Apart from oxygenic photosynthesis, the extent of manganese utilization in bacteria varies
from species to species and also appears to depend on external conditions. This …

Streptococcal solute-binding proteins (SBPs) associated with ATP-binding cassette
transporters gained widespread attention first as ostensible adhesins, next as virulence …