The polyamines spermidine and spermine are positively charged aliphatic molecules. They
are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein …

Andersen–Tawil syndrome (ATS) is a rare hereditary multisystem disorder. Ventricular
arrhythmias, periodic paralysis and dysmorphic features constitute the classic triad of ATS …

Aims The shRNA-mediated loss of expression of the desmosomal protein plakophilin-2
leads to sodium current (INa) dysfunction. Whether pkp2 gene haploinsufficiency leads to …

In a family with inappropriate sinus tachycardia (IST), we identified a mutation (p. V240M) of
the hyperpolarization-activated cyclic nucleotide–gated type 4 (HCN4) channel, which …

Abstract Background Andersen-Tawil Syndrome type 1 (ATS1) is a rare arrhythmogenic
disorder, caused by loss-of-function mutations in the KCNJ2 gene. We present here the …

Aims Cardiac excitability and refractoriness are largely determined by the function and
number of inward rectifier K+ channels (Kir2. 1–2.3), which are differentially expressed in the …

Inward rectifying potassium (Kir) channels play important roles in both excitable and
nonexcitable cells of various organ systems and could represent valuable new drug targets …

Andersen-Tawil syndrome (ATS) is a rare inheritable disease associated with loss-of-
function mutations in KCNJ2, the gene coding the strong inward rectifier potassium channel …

Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2
inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients. Sodium …

Since its initial description by Jervell and Lange‐Nielsen in 1957, the congenital long QT
syndrome (LQTS) has been the most investigated cardiac ion channelopathy. A prolonged …