Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study
HC Kung, J Yu - MedComm, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy with a
high rate of recurrence and a dismal 5‐year survival rate. Contributing to the poor prognosis …
high rate of recurrence and a dismal 5‐year survival rate. Contributing to the poor prognosis …
Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline☆
C Sessa, J Balmaña, SL Bober… - Annals of …, 2023 - annalsofoncology.org
Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …
history criteria, and molecularly defined by identification of germline pathogenic variants …
Pancreatic cancer: changing epidemiology and new approaches to risk assessment, early detection, and prevention
EM Stoffel, RE Brand, M Goggins - Gastroenterology, 2023 - Elsevier
Pancreatic cancer usually results in poor survival with limited options for treatment, as most
affected individuals present with advanced disease. Early detection of preinvasive …
affected individuals present with advanced disease. Early detection of preinvasive …
Germline aberrations in pancreatic cancer: implications for clinical care
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis and represents
a major public health issue, as both its incidence and mortality are expecting to increase …
a major public health issue, as both its incidence and mortality are expecting to increase …
[HTML][HTML] Surveillance for pancreatic cancer in high-risk individuals leads to improved outcomes: a propensity score-matched analysis
DCF Klatte, B Boekestijn, AM Onnekink, FW Dekker… - Gastroenterology, 2023 - Elsevier
Background & Aims Recent pancreatic cancer surveillance programs of high-risk individuals
have reported improved outcomes. This study assessed to what extent outcomes of …
have reported improved outcomes. This study assessed to what extent outcomes of …
Automated artificial intelligence model trained on a large data set can detect pancreas cancer on diagnostic computed tomography scans as well as visually occult …
Background & Aims The aims of our case-control study were (1) to develop an automated 3-
dimensional (3D) Convolutional Neural Network (CNN) for detection of pancreatic ductal …
dimensional (3D) Convolutional Neural Network (CNN) for detection of pancreatic ductal …
Outcomes of a 3-year prospective surveillance in individuals at high risk of pancreatic cancer
S Paiella, G Capurso, S Carrara… - Official journal of the …, 2024 - journals.lww.com
METHODS: HRI (subjects with a family history or mutation carriers with/without a family
history were enrolled in 18 centers). They underwent annual magnetic resonance with …
history were enrolled in 18 centers). They underwent annual magnetic resonance with …
Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer
AM Bogdanski, JE van Hooft, B Boekestijn, BA Bonsing… - Familial Cancer, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and
is associated with a poor prognosis. The majority of these cancers are detected at a late …
is associated with a poor prognosis. The majority of these cancers are detected at a late …
The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals
G Zogopoulos, I Haimi, SA Sanoba, JN Everett… - Journal of the National …, 2024 - jnccn.org
Background: Pancreatic adenocarcinoma (PC) is a highly lethal malignancy with a survival
rate of only 12%. Surveillance is recommended for high-risk individuals (HRIs), but it is not …
rate of only 12%. Surveillance is recommended for high-risk individuals (HRIs), but it is not …
Pancreatic cancer screening for at-risk individuals (pancreas scan study): yield, harms, and outcomes from a prospective multicenter study
I Shah, A Silva-Santisteban… - Official journal of the …, 2023 - journals.lww.com
METHODS: All high-risk individuals undergoing pancreatic cancer screening at 5 centers
from 2020 to 2022 were prospectively enrolled. Pancreas findings were designated as low …
from 2020 to 2022 were prospectively enrolled. Pancreas findings were designated as low …