Patterning of the cell cortex by Rho GTPases

WM Bement, AB Goryachev, AL Miller… - … Reviews Molecular Cell …, 2024 - nature.com
Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Design principles for selective polarization of PAR proteins by cortical flows

R Illukkumbura, N Hirani, J Borrego-Pinto… - Journal of Cell …, 2023 - rupress.org
Clustering of membrane-associated molecules is thought to promote interactions with the
actomyosin cortex, enabling sizedependent transport by actin flows. Consistent with this …

Composite branched and linear F-actin maximize myosin-induced membrane shape changes in a biomimetic cell model

R Sakamoto, MP Murrell - Communications Biology, 2024 - nature.com
The architecture of the actin cortex determines the generation and transmission of stresses,
during key events from cell division to migration. However, its impact on myosin-induced cell …

A Hierarchical Mechanotransduction System: From Macro to Micro

R Cao, H Tian, Y Tian, X Fu - Advanced Science, 2024 - Wiley Online Library
Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including
mechanical forces and properties, are sensed and translated into biochemical signals …

Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in Caenorhabditis elegans zygotes

B Yao, S Donoughe, J Michaux… - Molecular Biology of the …, 2022 - Am Soc Cell Biol
Pulsatile RhoA dynamics underlie a wide range of cell and tissue behaviors. The circuits that
produce these dynamics in different cells share common architectures based on fast positive …

F-actin architecture determines the conversion of chemical energy into mechanical work

R Sakamoto, MP Murrell - Nature Communications, 2024 - nature.com
Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell
division to migration. A fundamental driver of cellular mechanical work is the actin …

Actomyosin clusters as active units shaping living matter

K Kruse, R Berthoz, L Barberi, AC Reymann… - Current Biology, 2024 - cell.com
Stress generation by the actin cytoskeleton shapes cells and tissues. Despite impressive
progress in live imaging and quantitative physical descriptions of cytoskeletal network …

Utilizing Computer Vision for Continuous Monitoring of Vaccine Side Effects in Experimental Mice

C Li, S Shao, W Mikason, R Lin, Y Liu - arXiv preprint arXiv:2404.03121, 2024 - arxiv.org
The demand for improved efficiency and accuracy in vaccine safety assessments is
increasing. Here, we explore the application of computer vision technologies to automate …

Mechanical forces in asymmetric cell division

V Šabata - 2023 - dspace.cuni.cz
Cell division is one of the most studied topics in the field of cellular and molecular biology. In
some cases, cells can exploit diverse mechanisms to alter the basic function of their division …