Telomeres are protective caps at the ends of human chromosomes. Telomeres shorten with
each successive cell division in normal human cells whereas, in tumors, they are …

It has been approximately a decade since telomerase was described as an almost universal
marker for human cancer. Most human tumours not only express telomerase but also have …

The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …

The continuous growth of advanced malignancies almost universally correlates with the
reactivation of telomerase. While there is still a great deal of basic and applied research to …

Purpose: High-level expression of the telomerase reverse transcriptase (hTERT) in> 85% of
human cancers, in contrast with its restricted expression in normal adult tissues, points to …

The ideal cancer treatment would specifically target cancer cells yet have minimal or no
adverse effects on normal somatic cells. Telomerase, the ribonucleoprotein reverse …

The catalytic component of human telomerase reverse transcriptase (hTERT) is not
expressed in most primary somatic human cells, whereas the majority of cancer cells …

One of the hallmarks of advanced malignancies is continuous cell growth and this almost
universally correlates with the reactivation of telomerase. Although there is still much we do …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …

It is well known that a decreased expression or inhibited activity of telomerase in cancer
cells is accompanied by an increased sensitivity to some drugs (eg, doxorubicin, cisplatin, or …