Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …

The acetylation of histone and non-histone proteins controls a great deal of cellular
functions, thereby affecting the entire organism, including the brain. Acetylation …

Neuromuscular junction (NMJ) disruption is an early pathogenic event in amyotrophic lateral
sclerosis (ALS). Yet, direct links between NMJ pathways and ALS-associated genes such as …

Declining muscle mass and function is one of the main drivers of loss of independence in
the elderly. Sarcopenia is associated with numerous cellular and endocrine perturbations …

In myotonic dystrophy type 1 (DM1), dystrophia myotonica protein kinase messenger
ribonucleic acids (RNAs; mRNAs) with expanded CUG repeats (CUGexp) aggregate in the …

Microtubules (MTs) are known to be post-translationally modified at the neuromuscular
junction (NMJ), hence increasing their stability. To date however, the function (s) of the …

The LMNA gene encodes lamins A and C, two intermediate filament-type proteins that are
important determinants of interphase nuclear architecture. Mutations in LMNA lead to a wide …

Abstract Background All children attending General Dental Practice in Scotland are
recommended to receive twice-yearly applications of sodium fluoride varnish to prevent …

Background While alternative splicing (AS) contributes greatly to protein diversities, the
relationship between various types of AS and epigenetic factors remains largely unknown …

Electroporation is a widely used technique for enhancing the efficiency of DNA delivery into
cells. Application of electric pulses after local injection of DNA temporarily opens cell …