The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Pestiviruses are among the economically most important pathogens of livestock. The biology
of these viruses is characterized by unique and interesting features that are both crucial for …

Classical swine fever (CSF) is among the most relevant viral epizootic diseases of swine.
Due to its severe economic impact, CSF is notifiable to the world organisation for animal …

Type I interferons (IFN-α/β) are potent antiviral cytokines and modulators of the adaptive
immune system. They are induced by viral infection or by double-stranded RNA (dsRNA), a …

Small RNA viruses have evolved many mechanisms to increase the capacity of their short
genomes. Here we describe the identification and characterization of a novel open reading …

Classical swine fever (CSF) represents a major health and trade problem for the pig
industry. In endemic countries or those with a wild boar reservoir, CSF remains a priority for …

Avian influenza viruses (AIV) raise worldwide veterinary and public health concerns due to
their potential for zoonotic transmission. While infection with highly pathogenic AIV results in …

Bovine viral diarrhea virus (BVDV) is a pestivirus that can establish a persistent infection in
the developing fetus and has the ability to disable the production of type I interferon. In this …

Viruses have evolved a multitude of strategies to subvert the innate immune system by
interfering with components of the alpha/beta interferon (IFN-α/β) induction and signaling …

The interferon system provides a powerful and universal intracellular defense mechanism
against viruses. Knockout mice defective in IFN signaling quickly succumb to all kinds of …