Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. It is also one of the most studied topics among cell biologists. An …

Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend
off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological …

Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …

Simple Summary The Inhibitor of Apoptosis (IAP) family of proteins has emerged as a
potential pharmacological target in cancer. Abnormal expression of IAPs can lead to …

In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis causes the
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …

DNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate
detachment and hypoxia can all trigger apoptosis in normal cells. However, cancer cells …

Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer,
in addition to other human diseases including neurodegeneration, coronary disease and …

Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

The final stage of spermatid terminal differentiation involves the removal of their bulk
cytoplasm in a process known as spermatid individualization. Here we show that apoptotic …