Understanding complex systems often requires a bottom-up analysis towards a systems
biology approach. The need to investigate a system, not only as individual components but …

While the number of sequenced genomes continues to grow, experimentally verified
functional annotation of whole genomes remains patchy. Structural genomics projects are …

Current yeast interactome network maps contain several hundred molecular complexes with
limited and somewhat controversial representation of direct binary interactions. We carried …

RNA-binding proteins (RBPs) have roles in the regulation of many post-transcriptional steps
in gene expression, but relatively few RBPs have been systematically studied. We searched …

Identification of essential proteins is key to understanding the minimal requirements for
cellular life and important for drug design. The rapid increase of available protein-protein …

Abstract The Biological General Repository for Interaction Datasets (BioGRID) database
(http://www. thebiogrid. org) was developed to house and distribute collections of protein …

Gene duplication and loss is a powerful source of functional innovation. However, the
general principles that govern this process are still largely unknown. With the growing …

Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. The CORUM (http://mips. gsf. de/genre/proj/corum/index. html) …

Background Identification of essential proteins is always a challenging task since it requires
experimental approaches that are time-consuming and laborious. With the advances in high …

Macromolecular assemblies involving membrane proteins (MPs) serve vital biological roles
and are prime drug targets in a variety of diseases. Large-scale affinity purification studies of …