Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Drugs targeting the cell cycle–regulatory cyclin-dependent kinase (CDK) 4 and 6 have been
approved for the treatment of hormone receptor–positive breast cancer, and inhibitors …

T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

We have conducted a detailed transcriptomic, proteomic and phosphoproteomic analysis of
CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module …

The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …

The Mediator-associated kinases CDK8 and CDK19 function in the context of three
additional proteins: CCNC and MED12, which activate CDK8/CDK19 kinase function, and …

CDK12 is a kinase associated with elongating RNA polymerase II (RNAPII) and is frequently
mutated in cancer. CDK12 depletion reduces the expression of homologous recombination …

Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating transcription either
through its association with the Mediator complex or by phosphorylating transcription factors …

Cancer denotes a pathological manifestation that is characterized by hyperproliferation of
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …