Gastrulation is a key milestone in the development of an organism. It is a period of cell
proliferation and coordinated cellular rearrangement, that creates an outline of the body …

During early mammalian embryonic development, fertilized one-cell embryos develop into
pre-implantation blastocysts and subsequently establish three germ layers through …

Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

PHD2 is essential in modulating HIF-1α levels upon oxygen fluctuations. Hypoxia, a
hallmark of uterus, and HIF-1α have recently emerged as opposing regulators of …

Stem cell-based mammalian embryo models facilitate the discovery of developmental
mechanisms because they are more amenable to genetic and epigenetic perturbations than …

Advances in three-dimensional culture technologies have facilitated the development of
synthetic embryo models, such as blastoids, through the co-culturing of diverse stem cell …

Mammalian stem cell-based embryo models have emerged as innovative tools for
investigating early embryogenesis in both mice and primates. They not only reduce the need …

Background: Recapitulating mammalian cell type differentiation in vitro promises to improve
our understanding of how these processes happen in vivo, while bringing additional …

Background: Recapitulating mammalian cell type differentiation in vitro promises to improve
our understanding of how these processes happen in vivo, while bringing additional …

Embryonic stem cells (ESCs) can self-organize in vitro into developmental patterns with
spatial organization and molecular similarity to that of early embryonic stages. This self …