The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

Given the tiny size of the mammalian mitochondrial genome, at only 16.5 kb, it is often
surprising how little we know about some of its molecular features, and the molecular …

As regulators of bioenergetics in the cell and the primary source of endogenous reactive
oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the …

Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective
replication, or by various endogenous or exogenous sources, such as reactive oxygen …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome (mtDNA) that codes for subunits of the oxidative phosphorylation machinery …

Human mitochondria harbor an essential, high copy number, 16,569 base pair, circular DNA
genome that encodes 13 gene products required for electron transport and oxidative …

Mitochondria have a plethora of functions within a eukaryotic cell, ranging from energy
production, cell signaling, and protein cofactor synthesis to various aspects of metabolism …

Mitochondria play a central role in bioenergetics, and fulfill a plethora of functions in cell
signaling, programmed cell death, and biosynthesis of key protein cofactors. Mitochondria …

Mitochondrial DNA (mtDNA) polymerase γ (POLγ) harbours a 3′–5′ exonuclease
proofreading activity. Here we demonstrate that this activity is required for the creation of …

Mitochondria play a crucial role in a variety of cellular processes ranging from energy
metabolism, generation of reactive oxygen species (ROS), and Ca 2+ handling to stress …