Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma

G Roex, M Timmers, K Wouters… - Journal of hematology & …, 2020 - Springer
Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-
cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic …

Plasma cell leukemia: definition, presentation, and treatment

MT Gundesen, T Lund, HEH Moeller… - Current oncology …, 2019 - Springer
Abstract Purpose of Review We discuss current topics on the definition of plasma cell
leukemia and the distinction between plasma cell leukemia and multiple myeloma …

EVIDENCE meta-analysis: evaluating minimal residual disease as an intermediate clinical end point for multiple myeloma

O Landgren, TJ Prior, T Masterson, C Heuck, OF Bueno… - Blood, 2024 - ashpublications.org
Estimating progression-free survival (PFS) and overall survival superiority during clinical
trials of multiple myeloma (MM) has become increasingly challenging as novel therapeutics …

Mechanisms of NK cell activation and clinical activity of the therapeutic SLAMF7 antibody, elotuzumab in multiple myeloma

KS Campbell, AD Cohen, T Pazina - Frontiers in immunology, 2018 - frontiersin.org
Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-
common hematologic malignancy. Despite advances in therapy, MM remains largely …

Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment

K Hemminki, J Hemminki, A Försti, A Sud - Leukemia, 2023 - nature.com
Studies of survival in hematological malignancies (HMs) have generally shown an
improvement over time, although most of these studies are limited by a short follow-up …

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases

K Hemminki, A Försti, R Houlston… - International journal of …, 2021 - Wiley Online Library
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …

Time trends in survival and causes of death in multiple myeloma: a population-based study from Germany

C Eisfeld, H Kajüter, L Möller, I Wellmann, E Shumilov… - BMC cancer, 2023 - Springer
Background Steady evolution of therapies has improved prognosis of patients with multiple
myeloma (MM) over the past two decades. Yet, knowledge about survival trends and causes …

Function of BCLAF1 in human disease

Z Yu, J Zhu, H Wang, H Li, X Jin - Oncology Letters, 2022 - spandidos-publications.com
Originally identified as a regulator of apoptosis and transcription, B‑cell lymphoma‑2‑
associated transcription factor 1 (BCLAF1) has since been shown to be associated with a …

Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients

EK Mai, T Hielscher, U Bertsch, HJ Salwender… - Leukemia, 2024 - nature.com
Early morbidity and mortality affect patient outcomes in multiple myeloma. Thus, we
dissected the incidence and causes of morbidity/mortality during induction therapy (IT) for …

The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signalling

A David, S Zocchi, A Talbot, C Choisy, A Ohnona… - Leukemia, 2021 - nature.com
Multiple myeloma (MM) is a currently incurable malignancy of antibody-secreting plasma
cells. Long non-coding RNAs (lncRNAs) have been recognised as an important class of …