Background Acute blood loss in trauma requires quick identification and action to restore
circulating volume and save the patient. Massive transfusion protocols (MTPs) have become …

Hemorrhagic shock (HS) management is based on a timely, rapid, definitive source control
of bleeding/s and on blood loss replacement. Stopping the hemorrhage from progressing …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

Background Renewed interest in low titer group O whole blood (LTOWB) transfusion has led
to increased utilization in adult trauma centers; little is known regarding LTOWB use in …

BACKGROUND Whole blood (WB) transfusion received renewed interest after recent armed
conflicts. The effectiveness as compared with blood component transfusion (BCT) is …

Introduction Low‐titer group O whole blood (LTOWB) is being increasingly transfused to
injured patients. This study evaluated a range of clinical outcomes to determine if receipt of …

There has been renewed interest in the use of low titer group O whole blood (LTOWB) for
the resuscitation of civilian casualties. LTOWB offers several advantages over conventional …

BACKGROUND Military experience has shown low-titer O whole blood (LTOWB) to be safe
and beneficial in the resuscitation of hemorrhaging trauma patients. However, few civilian …

Background Military data demonstrating an improved survival rate with whole blood (WB)
have led to a shift toward the use of WB in civilian trauma. The purpose of this study is to …

Background Early close ratio transfusion with balanced component therapy (BCT) has been
associated with improved outcomes in patients with severe hemorrhage; however, this …