The study of cerebellar development has been at the forefront of neuroscience since the
pioneering work of Wilhelm His Sr., Santiago Ramón y Cajal and many others since the 19th …

The well-organized cerebellar structures and neuronal networks are likely crucial for their
functions in motor coordination, motor learning, cognition, and emotion. Such cerebellar …

The major cause of treatment failure and mortality among medulloblastoma patients is
metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor …

Transit amplification of neural progenitors/precursors is widely used in the development of
the central nervous system and for tissue homeostasis. In most cases, stem cells, which are …

Aims Inherited or somatic mutations in the MRE11, RAD50 and NBN genes increase the
incidence of tumours, including medulloblastoma (MB). On the other hand, MRE11, RAD50 …

Cerebellar granule neuron progenitors (GNPs) originate from the upper rhombic lip (URL), a
germinative niche in which developmental defects produce human diseases. T-cell factor …

Neural circuits are known to be remodeled and become functionally mature during postnatal
development. Extensive synapse formation (or synaptogenesis) occurs during the perinatal …

Kinesin-2 motors have been demonstrated to regulate Hedgehog (HH) signaling,
particularly within the developing cerebellum (Spassky et al., 2008; Waas et al., 2024) …

The cerebellum consists of about ten types of neurons that have distinct characteristics in
terms of their location, morphology, immunoreactivity and physiology. They can be …

Granule cell progenitors (GCPs) and granule cells (GCs) in the cerebellum are excellent
models for studying the differentiation of neural progenitors into neurons. Although gradual …