Virulence of the zoonotic agent of leptospirosis: still terra incognita?

M Picardeau - Nature Reviews Microbiology, 2017 - nature.com
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging
zoonotic disease that affects animals and humans worldwide. The success of leptospires as …

Understanding GroEL and DnaK stress response proteins as antigens for bacterial diseases

KR Fourie, HL Wilson - Vaccines, 2020 - mdpi.com
Bacteria do not simply express a constitutive panel of proteins but they instead undergo
dynamic changes in their protein repertoire in response to changes in nutritional status and …

Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

GO Andre, TR Converso, WR Politano… - Frontiers in …, 2017 - frontiersin.org
The complement system plays a central role in immune defense against Streptococcus
pneumoniae. In order to evade complement attack, pneumococci have evolved a number of …

Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases

DA Ayón-Núñez, G Fragoso, RJ Bobes… - Bioscience …, 2018 - portlandpress.com
Pathogens have developed particular strategies to infect and invade their hosts. Amongst
these strategies' figures the modulation of several components of the innate immune system …

Complement Evasion by Pathogenic Leptospira

TR Fraga, L Isaac, AS Barbosa - Frontiers in immunology, 2016 - frontiersin.org
Leptospirosis is a neglected infectious disease caused by spirochetes from the genus
Leptospira. Pathogenic microorganisms, notably those which reach the blood circulation …

LigB subunit vaccine confers sterile immunity against challenge in the hamster model of leptospirosis

NL Conrad, FW Cruz McBride, JD Souza… - PLoS neglected …, 2017 - journals.plos.org
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact
on rural and poor urban communities, particularly in developing countries. This has led to …

Plasmin (ogen) at the nexus of fibrinolysis, inflammation, and complement

JH Foley - Seminars in thrombosis and hemostasis, 2017 - thieme-connect.com
The diverse mechanisms by which the plasmin (ogen) system is involved in human
physiology and pathology are constantly being delineated. For many years, the plasmin …

A universal vaccine against leptospirosis: are we going in the right direction?

AA Grassmann, JD Souza, AJA McBride - Frontiers in immunology, 2017 - frontiersin.org
Leptospirosis is the most widespread zoonosis in the world and a neglected tropical disease
estimated to cause severe infection in more than one million people worldwide every year …

LppA is a novel plasminogen receptor of Mycoplasma bovis that contributes to adhesion by binding the host extracellular matrix and Annexin A2

S Liu, Z Li, S Lan, H Hao, X Jin, J Liang, AA Baz… - Veterinary …, 2023 - Springer
Mycoplasma bovis is responsible for various inflammatory diseases in cattle. The prevention
and control of M. bovis are complicated by the absence of effective vaccines and the …

Leptospiral immunoglobulin-like domain proteins: Roles in virulence and immunity

DA Haake, J Matsunaga - Frontiers in Immunology, 2021 - frontiersin.org
The virulence mechanisms required for infection and evasion of immunity by pathogenic
Leptospira species remain poorly understood. A number of L. interrogans surface proteins …