Applications of genome-scale metabolic network model in metabolic engineering
Genome-scale metabolic network model (GEM) is a fundamental framework in systems
metabolic engineering. GEM is built upon extensive experimental data and literature …
metabolic engineering. GEM is built upon extensive experimental data and literature …
Integration of metabolomics data into metabolic networks
N Töpfer, S Kleessen, Z Nikoloski - Frontiers in plant science, 2015 - frontiersin.org
Metabolite levels together with their corresponding metabolic fluxes are integrative
outcomes of biochemical transformations and regulatory processes and they can be used to …
outcomes of biochemical transformations and regulatory processes and they can be used to …
Improved vanillin production in baker's yeast through in silico design
AR Brochado, C Matos, BL Møller, J Hansen… - Microbial cell …, 2010 - Springer
Background Vanillin is one of the most widely used flavouring agents, originally obtained
from cured seed pods of the vanilla orchid Vanilla planifolia. Currently vanillin is mostly …
from cured seed pods of the vanilla orchid Vanilla planifolia. Currently vanillin is mostly …
[HTML][HTML] Systematic engineering for production of anti-aging sunscreen compound in Pseudomonas putida
Sunscreen has been used for thousands of years to protect skin from ultraviolet radiation.
However, the use of modern commercial sunscreen containing oxybenzone, ZnO, and TiO 2 …
However, the use of modern commercial sunscreen containing oxybenzone, ZnO, and TiO 2 …
Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement
BKS Chung, S Selvarasu, A Camattari, J Ryu… - Microbial cell …, 2010 - Springer
Background Pichia pastoris has been recognized as an effective host for recombinant
protein production. A number of studies have been reported for improving this expression …
protein production. A number of studies have been reported for improving this expression …
A data-integrative modeling approach accurately characterizes the effects of mutations on Arabidopsis lipid metabolism
S Correa Córdoba, A Burgos… - Plant …, 2024 - academic.oup.com
Collections of insertional mutants have been instrumental for characterizing the functional
relevance of genes in different model organisms, including Arabidopsis (Arabidopsis …
relevance of genes in different model organisms, including Arabidopsis (Arabidopsis …
The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production …
Background Zymomonas mobilis ZM4 is a Gram-negative bacterium that can efficiently
produce ethanol from various carbon substrates, including glucose, fructose, and sucrose …
produce ethanol from various carbon substrates, including glucose, fructose, and sucrose …
Assessing the metabolic impact of nitrogen availability using a compartmentalized maize leaf genome-scale model
M Simons, R Saha, N Amiour, A Kumar… - Plant …, 2014 - academic.oup.com
Maize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy
crop. A second-generation genome-scale metabolic model for the maize leaf was created to …
crop. A second-generation genome-scale metabolic model for the maize leaf was created to …
Computational codon optimization of synthetic gene for protein expression
Background The construction of customized nucleic acid sequences allows us to have
greater flexibility in gene design for recombinant protein expression. Among the various …
greater flexibility in gene design for recombinant protein expression. Among the various …
A network perspective on metabolism and aging
QA Soltow, DP Jones… - … and comparative biology, 2010 - academic.oup.com
Aging affects a myriad of genetic, biochemical, and metabolic processes, and efforts to
understand the underlying molecular basis of aging are often thwarted by the complexity of …
understand the underlying molecular basis of aging are often thwarted by the complexity of …