pH sensing and regulation in cancer
Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …
Acid-sensing ion channels in pain and disease
Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3. 2 channel activity
A García-Caballero, VM Gadotti, P Stemkowski… - Neuron, 2014 - cell.com
T-type calcium channels are essential contributors to the transmission of nociceptive signals
in the primary afferent pain pathway. Here, we show that T-type calcium channels are …
in the primary afferent pain pathway. Here, we show that T-type calcium channels are …
International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel
S Kellenberger, L Schild, EH Ohlstein - Pharmacological reviews, 2015 - Elsevier
Abstract The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …
Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems
E Deval, E Lingueglia - Neuropharmacology, 2015 - Elsevier
Since their molecular cloning in the late 90's, Acid-Sensing Ion Channels (ASICs) have been
shown to be involved in many aspects of nociception, both in peripheral and central …
shown to be involved in many aspects of nociception, both in peripheral and central …
Neuroprotective and anti‐apoptotic effects of liraglutide on SH‐SY 5Y cells exposed to methylglyoxal stress
MK Sharma, J Jalewa, C Hölscher - Journal of neurochemistry, 2014 - Wiley Online Library
Abstract Glucagon‐like peptide 1 (GLP‐1) is a growth factor that has demonstrated
neuroprotective properties in a range of studies. In an APPswe/PS1ΔE9 mouse model of …
neuroprotective properties in a range of studies. In an APPswe/PS1ΔE9 mouse model of …
Acid-sensing ion channels: trafficking and synaptic function
X Zha - Molecular brain, 2013 - Springer
Extracellular acidification occurs in the brain with elevated neural activity, increased
metabolism, and neuronal injury. This reduction in pH can have profound effects on brain …
metabolism, and neuronal injury. This reduction in pH can have profound effects on brain …
BDNF: no gain without pain?
PA Smith - Neuroscience, 2014 - Elsevier
Injury to the adult nervous system promotes the expression and secretion of brain-derived
neurotrophic factor (BDNF). Because it promotes neuronal growth, survival and …
neurotrophic factor (BDNF). Because it promotes neuronal growth, survival and …
[HTML][HTML] Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
HJ Kweon, BC Suh - BMB reports, 2013 - ncbi.nlm.nih.gov
Extracellular acidification occurs not only in pathological conditions such as inflammation
and brain ischemia, but also in normal physiological conditions such as synaptic …
and brain ischemia, but also in normal physiological conditions such as synaptic …
Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes
CJ Laedermann, H Abriel, I Decosterd - Frontiers in pharmacology, 2015 - frontiersin.org
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium
channels (Navs) is very important for the transmission of nociceptive information since they …
channels (Navs) is very important for the transmission of nociceptive information since they …