Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …

Heart disease continues to be the leading cause of mortality worldwide, primarily attributed
to the restricted regenerative potential of the adult human heart following injury. In contrast to …

The therapeutic potential of bone marrow mesenchymal stromal cells (bmMSCs) to address
heart failure needs improvement for better engraftment and survival. This study explores the …

Heart degenerative diseases pose a significant challenge due to the limited ability of native
heart to restore lost cardiomyocytes. Direct cellular reprogramming technology, particularly …

Organ-on-a-chip platform scans offer a controllable environment and a physiological
similarity to mimic human pathophysiology. In this study, a single-channel PDMS microchip …

The heart is the first organ formed during mammalian development and functions to
distribute nutrients and oxygen to other parts of the developing embryo. Cardiomyocytes are …

The physiologic relationship between the brain and heart is emerging as a novel therapeutic
target for clinical intervention for acute myocardial infarction. In the adult human brain …

Objective Eighty percent of patients with a diagnosis of tetralogy of Fallot (TOF) do not have
a known genetic etiology or syndrome. We sought to identify key molecular pathways and …

Maturation is the last step of heart growth that prepares the organ over the lifetime of the
mammal for powerful, effective, and sustained pumping. Structural, gene expression …

Objectives Experimental models to test the effective protection against cardiac ischemia
injury are still challenging in pre-clinical studies. The use of myocardial slices creates a …