Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …

Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

Tinnitus is an auditory phantom sensation (ringing of the ears) experienced when no
external sound is present. Most but not all cases are associated with hearing loss induced …

Results: Numbers of peripheral lymphocytes and those of T4 lymphocytes were increased in
the groups given cimetidine or ranitidine; however, no fixed result was obtained in the …

ABSTRACT Lacosamide (LCM),(SPM 927,(R)‐2‐acetamido‐N‐benzyl‐3‐
methoxypropionamide, previously referred to as harkoseride or ADD 234037) is a member …

Clinical and experimental data indicate that changes in the expression of voltage-gated
sodium channels play a key role in the pathogenesis of neuropathic pain and that drugs that …

In this review, we highlight the contribution of advances in human neuroimaging to the
current understanding of central mechanisms underpinning tinnitus and explain how …

Introduction The neuroinflammatory response plays a key role in several pain syndromes.
Intravenous (iv) lidocaine is beneficial in acute and chronic pain. This review delineates the …

Voltage-gated sodium channels play a critical role in excitability of nociceptors (pain-
sensing neurons). Several different sodium channels are thought to be potential targets for …

Abstract Background and Aims Anaesthesia for medical purposes was introduced in the
19th century. However, the physiological mode of anaesthetic drug actions on the nervous …