The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

Tumours evade immune control by creating hostile microenvironments that perturb T cell
metabolism and effector function,,–. However, it remains unclear how intra-tumoral T cells …

More than one third of ovarian cancer patients present with ascites at diagnosis, and almost
all have ascites at recurrence. The presence of ascites correlates with the peritoneal spread …

Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …

Background: The presence of CD8+ tumor-infiltrating lymphocytes (TIL) is associated with
prolonged survival in high-grade serous ovarian cancer (HGSC) and other epithelial …

Cancer cells, both in vivo and in vitro, have been demonstrated to release membranous
structures, defined as microvesicles or exosomes, consisting of an array of macromolecules …

Background Tumor-infiltrating T cells are associated with survival in epithelial ovarian
cancer (EOC), but their functional status is poorly understood, especially relative to the …

The peritoneal cavity is a fluid filled space that holds most of the abdominal organs,
including the omentum, a visceral adipose tissue that contains milky spots or clusters of …

Background: Tumour-infiltrating lymphocytes (TILs) are associated with improved survival in
several epithelial cancers. The two chemokines CXCL9 and CXCL10 facilitate chemotactic …