The brainstem dorsal vagal complex (DVC) is known to regulate energy balance and is the
target of appetite-suppressing hormones, such as glucagon-like peptide 1 (GLP-1). Here we …

Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in
asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive …

Background Metabolic diseases such as obesity are known to be driven by both
environmental and genetic factors. Although genome-wide association studies of common …

AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic
changes in appetite associated with fluctuations in food availability and leptin signaling …

Highlights•Genome-wide association studies have identified multiple genetic variants
associated with circulating levels of adipokines.•There is limited genetic proof of causal …

Increasing numbers of studies seek to characterize the different cellular sub-populations
present in mammalian tissues. The techniques “Isolation of Nuclei Tagged in Specific Cell …

The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine
systems. Given its role governing key traits, such as body weight and reproductive timing …

The development and diversity of neuronal subtypes in the human hypothalamus has been
insufficiently characterized. To address this, we integrated transcriptomic data from 241,096 …

Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance.
However, the genes and gene variants that influence its plasma levels are still not well …

Nutrient scarcity is a frequent adverse condition that organisms face during their
development. This condition may lead to long-lasting effects on the metabolism and …