Scanning probe microscopy (SPM), a key invention in nanoscience, has by now been
extended to a wide spectrum of basic and applied fields. Its application to basic science led …

Cellulosomes are multienzyme complexes that are produced by anaerobic cellulolytic
bacteria for the degradation of lignocellulosic biomass. They comprise a complex of …

Connecting dynamics to structural data from diverse experimental sources, molecular
dynamics simulations permit the exploration of biological phenomena in unparalleled detail …

Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally
occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer …

The proper functioning of biomolecules in living cells requires them to assume particular
structures and to undergo conformational changes. Both biomolecular structure and motion …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

Single-molecule force spectroscopy with the atomic force microscope provides molecular
level insights into protein function, allowing researchers to reconstruct energy landscapes …

One of the most exciting developments in the field of biological physics in recent years is the
ability to manipulate single molecules and probe their properties and function. Since its …

High resilience to mechanical stress is key when pathogens adhere to their target and
initiate infection. Using atomic force microscopy–based single-molecule force spectroscopy …

Single-molecule force spectroscopy sheds light onto the free energy landscapes governing
protein folding and molecular recognition. Since only a single molecule or single molecular …